S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite S-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mice model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further VPA hydroxamates and amides. Authors:
نویسندگان
چکیده
DE, KZ, HN University of Veterinary Medicine Hannover Foundation -, Center for Systemic Neuroscience Hannover, Centre for Food Science, Department of Food Toxicology and Chemical Analysis Food Toxicology -, Bischofsholer Damm 15, D-30173 Hannover, Germany KH University of Veterinary Medicine Hannover Foundation -, Center for Systemic Neuroscience Hannover, Institute of Pharmacology, Toxicology and Pharmacy, Bünteweg 17, D-30173 Hannover, Germany AL Federal Institute for Risk Assessment (BfR), Department of Food Safety, Thielallee 88 – 92, D-14195 Berlin, Germany DMD Fast Forward. Published on January 25, 2006 as doi:10.1124/dmd.105.008078
منابع مشابه
S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite s-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mouse model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further valproic acid hydroxamates and amides.
Structure-activity relationship studies of valproic acid (VPA) derivatives have revealed a quantitative correlation between histone deacetylase (HDAC) inhibition and induction of neural tube defects (NTDs) in the NMRI-exencephaly-mouse model, but this correlation has been, so far, limited to congeners with a carboxylic acid function. Whereas the classical HDAC inhibitor trichostatin A is active...
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